The effect of Mirabegron on liver tissue in adult female rats and the protective role of the reishi fungus Ganoderma lucidum.
Published
Oct 6, 2025Pages
1-11Abstract
This study was conducted to identify the effect of the drug Mirabegron on liver tissue and the role of the G.lucidum In addition to their expansion, sinusoidal expansion, vacuolar degeneration, infiltration, accumulation of inflammatory cells, Kupffer cell hyperplasia, fibrosis,and thrombonecrosis. While tissue sections of the group treated with the drug at a concentration of 10 mg/kg showed A more severe pathological change in tissues, represented by massive coagulative necrosis of liver cells, hyperplasia, the appearance of giant liver cells, fibrosis, the appearance of ghost cells, and interstitial hemorrhage, while the results of microscopic examinations of tissue sections treated with both concentrations of the drug and the reishi fungus G.lucidum resulted in a noticeable improvement in the organs studied, as well as Sometimes the tissue appears normal while some minor histological damage remains, such as the deposition of an acidic substance in the interstitial tissue and vacuolar degeneration in the bile cells.
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